London (CNN) -- At least 100 vehicles smashed into each other in a massive pile-up Thursday in England's southeastern county of Kent, police said, injuring six people seriously and leaving 200 others with minor injuries.
The huge chain-reaction crash took place on a multi-lane bridge and highway that connects the Isle of Sheppey with mainland Kent, reportedly amid thick fog.
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Video from the scene showed scores of abandoned cars and trucks, many crumpled from impacts with other vehicles. Motorists, some injured, sat on the roadside as they awaited help.
The Sheppey Crossing, on the A249 road, has been closed to traffic in both directions, Kent Police said.
More than 30 people were taken to the hospital and large numbers were treated at the scene of the crash, the local ambulance service said via Twitter.
"It's horrific. I've never seen anything like it in my life," local newspaper Kent Online quoted witness Martin Stammers, 45.
"All you could hear was cars crashing. We got out of our car and it was eerily quiet with visibility down to just 20 yards. Then you would hear the screeching of brakes and then a thud. It was all you could hear for about 10 minutes -- crash after crash after crash."
CNN's Pierre Meilhan contributed to this report.